Textbook of Medicinal Chemistry, Vol. I(Paperback)

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About the Book :Dr Alagarsamys Textbook of Medicinal Chemistry is a widely appreciated text on the subject. Primarily meant for the B Pharm students, this book is also useful for M Pharm and M Sc students studying organic chemistry and pharmaceutical chemistry. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing valuable information on relevant topics in medicinal chemistry.Interesting Facts : Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and Structure-Activity Relationship (SAR) of the drugs for the various body systems Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents, also includes recent topics like anti-HIV agents Contains brief introduction about physiological and pathophysiological conditions of diseases and their treatment Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject Covers the syllabi of all major Indian universitiesContents :ContentsIntroduction to Medicinal Chemistry Processes of Drug Discovery Drug Discovery and DesignA Historical Outline Modern Drug Discovery Screening and Designing Nature as a Source of Drug Compounds Drug DesigningSECTION I Physicochemical Factors in Relation to BiologicalActivity of Drugs Chapter 1 Physicochemical Properties Chapter 2 Ferguson Principle Chapter 3 Hydrogen Bonding Chapter 4 Ionization and pKa Value Chapter 5 Redox Potential Chapter 6 Surface Tension Chapter 7 Complexation Chapter 8 SolubilityChapter 9 Partition CoeffiientChapter 10 Steric Features of Drugs Chapter 11 Bioisosterism SECTION II Drug Design Chapter 12 Concepts of Drug Design Design of Analogues and Prodrugs Design of Lead and Lead Discovery Rational Approach to Drug DesignChapter 13 Receptors Types of Receptors Theories of Receptors Forces Involved in Drug Receptors Interaction Factors Affecting the Drug-Receptors InteractionChapter 14 Computer-Aided Drug Design Bioinformatics HubChapter 15 StructureActivity Relationship andQuantitative StructureActivity Relationship Historical Development of QSAR Basic Requirements for QSAR Analysis Model Development ProceduresChapter 16 Combinatorial Chemistry Combinatorial Compound LibrariesChapter 17 High Throuput ScreeningChapter 18 Prodrugs Classification of Prodrugs Application of ProdrugsSECTION III Drugs Acting on Central Nervous System Chapter 19 Central Nervous System Chapter 20 Sedatives and Hypnotics Molecular Basis of InhibitoryNeurotransmitters Classification Synthesis andDrug Profile SAR of Barbiturates; SAR of BenzodiazepinesChapter 21 General Anaesthetics Stages of Anaesthesia Classification Synthesis and Drug ProfileChapter 22 Local Anaesthetics Classification Synthesis and DrugProfile SAR of Benzoic Acid Derivatives SAR of AnilidesChapter 23 Tranquillizers General Mode of Action Classification Synthesis and Drug Profile SAR of Phenothiazines; SAR of ButyrophenonesChapter 24 Antidepressants Classification Synthesis and Drug Profile SAR of Dibenzazepines; SAR of Dibenzocylcoheptane DerivativesChapter 25 CNS Stimulants Classification Synthesis and Drug ProfileChapter 26 Narcotic Analgesics Synthesis and Drug Profile SAR of Morphine Derivatives; SAR of Meperidine Analogues; SAR of Methadone Derivatives; SAR of Benzomorphan Derivatives Narcotic Antagonists Classification Synthesis and Drug ProfileChapter 27 Anticonvulsants Classification Synthesis and Drug Profile SAR of Hydantoins; SAR of Oxazolidine Diones; SAR of Phenacemide AnaloguesChapter 28 Anti-Prakinsonism Agents Classification Synthesis and Drug ProfileChapter 29 Skeletal Muscle Relaxants Classification Synthesis and Drug ProfileChapter 30 Alzheimers Disease Pathogenesis; TreatmentSECTION IV Drugs Acting on Autonomic Nervous System Chapter 31 Autonomic Nervous System Chapter 32 Adrenergic Drugs Physiological Basis of Adrenergic Receptors Function General Classification of Adrenergic Agonists Synthesis and Drug Profile StructuralActivity RelationshipChapter 33 Cholinergic Drugs Spectrum of Cholinomimetic Drugs Classification Synthesis and Drug Profile Structure Activity RelationshipChapter 34 Andrenergic Blockers Physiological Basis of Adrenergic Receptor Antagonists Classification Synthesis and Drug Profile StructureActivity RelationshipChapter 35 Anticholinergic Drugs Difference Between the Quaternary andthe Tertiary Antimuscarinics Classification Synthesis and Drug Profile SAR of Atropine Analogues; SAR of Muscarinic AntagonistsSECTION V Drugs Acting on Cardiovascular System Chapter 36 Cardiovascular System Chapter 37 Antihypertensive Drugs Classification Synthesis and Drug ProfileChapter 38 Antiarrhythmic Drugs Classification Synthesis and Drug ProfileChapter 39 Antihyperlipidaemic Agents Classification Synthesis and Drug ProfileChapter 40 Antianginals Principles of Therapy for Angina Classification Synthesis and Drug Profile SAR of Dihydropyridine DerivativesSECTION VI Drugs Acting on Urinary System Chapter 41 Urinary System Chapter 42 Diuretics Classification Synthesis and Drug Profile; SAR of ThiazideDerivatives; SAR Carbonic Anhydrase Inhibitors; SAR of LoopDiureticsAbout the Author :Dr V. Alagarsamy, M Pharm, PhD, FIC, DOMH, is Professor and Principal of MNR College of Pharmacy, Sangareddy, Greater Hyderabad. He received his D Pharm from Coimbatore Medical College, Tamil Nadu, and PhD from The MS University of Baroda, Gujarat. He has been teaching Medicinal Chemistry and performing research work in synthetic medicinal chemistry on novel heterocyclic bioactive compounds for more than a decade. His research activities are collaborated with various research laboratories/organizations like National Cancer Institute, USA; Rega Institute for Medical Research, Belgium; and Southern Research Institute, USA. He is a recipient of Young Scientist award from the Department of Science and Technology, New Delhi. His research publications in journals and presentations in conferences, put together, exceed hundred. His research activities are supported by the funding agencies like CSIR, DST, and DSIR. He is a doctoral committee member and a recognized research guide for PhD students in various universities.


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